Cells' powerhouses were once energy parasites: Study upends current theories of how mitochondria began

Cells' powerhouses were once energy parasites: Study upends current theories of how mitochondria began


Cells' powerhouses were once energy parasites: Study upends current theories of how mitochondria began

Cells' powerhouses were once energy parasites: Study upends current theories of how mitochondria began

Parasitic bacteria were the first cousins of the mitochondria that power cells in animals and plants -- and first acted as energy parasites in those cells before becoming beneficial, according to a new University of Virginia study that used next-generation DNA sequencing technologies to decode the genomes of 18 bacteria that are close relatives of mitochondria.

The study appears this week in the online journal PLoS ONE, published by the Public Library of Science. It provides an alternative theory to two current theories of how simple bacterial cells were swallowed up by host cells and ultimately became mitochondria, the "powerhouse" organelles within virtually all eukaryotic cells -- animal and plant cells that contain a nucleus and other features. Mitochondria power the cells by providing them with adenosine triphosphate, or ATP, considered by biologists to be the energy currency of life.

The origin of mitochondria began about 2 billion years ago and is one of the seminal events in the evolutionary history of life. However, little is known about the circumstances surrounding its origin, and that question is considered an enigma in modern biology.

"We believe this study has the potential to change the way we think about the event that led to mitochondria," said U.Va. biologist Martin Wu, the study's lead author. "We are saying that the current theories -- all claiming that the relationship between the bacteria and the host cell at the very beginning of the symbiosis was mutually beneficial -- are likely wrong.

"Instead, we believe the relationship likely was antagonistic -- that the bacteria were parasitic and only later became beneficial to the host cell by switching the direction of the ATP transport."
The finding, Wu said, is a new insight into an event in the early history of life on Earth that ultimately led to the diverse eukaryotic life we see today. Without mitochondria to provide energy to the rest of a cell, there could not have evolved such amazing biodiversity, he said.

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